Org current injuries -- Inter-league
Regular season -- as of 10/20/2021
| Injuries |
| | | | | | Duration |
| Date | Team | Name | Cause | Return | Orig | Left |
| 10/7/2021 | NYY | Kluber | General | 10/21/2021 | 14 | 1 |
| 9/8/2021 | STL | Lockett | Brawl | 10/22/2021 | 44 | 2 |
| 9/29/2021 | NYM | Robert | General | 10/22/2021 | 23 | 2 |
| 9/29/2021 | NYY | Tatis Jr. | General | 10/22/2021 | 23 | 2 |
| 9/22/2021 | SDP | Campusano | Hit by pitch | 10/24/2021 | 32 | 4 |
| 10/8/2021 | CIN | Gonzalez,G | General | 10/24/2021 | 16 | 4 |
| 10/7/2021 | KCR | Green,C | General | 10/27/2021 | 20 | 7 |
| 9/30/2021 | PIT | Murphy,P | Brawl | 10/31/2021 | 31 | 11 |
| 10/13/2021 | PIT | Valdez,F | General | 10/31/2021 | 18 | 11 |
| 10/16/2021 | NYY | Margot | General | 11/1/2021 | 16 | 12 |
| 10/16/2021 | PIT | Kershaw | General | 11/8/2021 | 23 | 19 |
| 10/3/2021 | ATL | Hembree | Brawl | 11/9/2021 | 37 | 20 |